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Over 26 weeks in 404 participants, clinically meaningful reductions in HbA 1c and body weight were observed, with the highest dose of elecoglipron (75 mg) achieving a mean reduction in HbA 1c of 20.8 mmol/mol, compared with 2.2 mmol/mol in the placebo group
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Together, these results suggest that the reduction in HGP observed in HFHC-fed Dpp4 –/– mice is driven by the loss of Dpp4 in hepatocytes and not Tie2 + EC populations
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